Endocrine Abstracts

Wnt/β-catenin signalling pathway is abnormally activated in most colorectal adenomas and tumours. Wnt factors are secreted glycoproteins that upon binding to their heterodimeric membrane receptors trigger a signal transduction pathway that leads to the accumulation of β-catenin in the cytosol and its nuclear translocation. Within the cell nucleus, β-catenin regulates a vast number of genes involved in cell proliferation and invasiveness via binding to members of...

Cinacalcet decreases and normalizes serum calcium levels across a broad severity range of primary hyperparathyroidism (PHPT), slightly reduces parathyroid hormone levels which generally remains elevated, whereas it has no effect on bone mineral density (BMD). Therefore, when administering Cinacalcet to a patient with PHPT, concomitant treatment with an anti-catabolic drug should be considered.An open-labeled, prospective trial was conducted in 30 patient...

Background: At the Third International Workshop on asymptomatic primary hyperparathyroidism (PHPT), recent data on the disease were reviewed, but limited information of the PHPT management in Europe is available.Methods: We performed an online questionnaire survey in hospital endocrinology services to determine knowledge of current PHPT recommendations and its management in the clinical practice during 2009 Spain.Results: Ninety-ni...

Nissen’s meta-analysis concluded that the use of Rosiglitazone (RSG) was associated with a significant increase in the risk of myocardial infarction. However, none of the analyzed studies took into account the cardiovascular events as primary outcomes, neither were controlled by cardiovascular risk factors.Objectives: 1. To know if there is an association between RSG myocardial infarction OR and the magnitude of the difference in baseline serum lipi...

Introduction: A increased prevalence of metabolic syndrome (MetS) has recently been described in patients with adult growth hormone deficiency (GHD). This fact could influence the increased risk of cardiovascular morbidity and mortality observed in these patients. Our objective was to investigate the characteristics and prevalence of MetS in adult GHD.Design and methods: Forty-nine adult patients (30 women, 19 men; 14 childhood-onset), mean age of 36.2&#...

Chronically exposure to stress promotes in individuals high intake of foods with high content of carbohydrates and fat and may develop obesity. Stress-induced sustained elevation of glucocorticoid serum levels may be due to impaired functioning of the hypothalamic glucocorticoid receptor GR, altering the hypothalamic-pituitary-adrenal axis regulation. As a result, chronically stressed individuals are unable to respond with higher cortisol levels wh...

Chronically exposure to stress promotes in individuals high intake of foods with high content of carbohydrates and fat and may develop obesity. Stress-induced sustained elevation of glucocorticoid serum levels may be due to impaired functioning of the hypothalamic glucocorticoid receptor GR, altering the hypothalamic-pituitary-adrenal axis regulation. As a result, chronically stressed individuals are unable to respond with higher cortisol levels wh...

Objective: The objective of our study is to evaluate muscle strength and risk of falls in type 2 diabetes mellitus (DM2) patientsMethods: Observational cross-sectional study. Hand grip strength (HGS) (kg/cm2) was measured with a Jamar. manual hydraulic dynamometer (5030j1; Jackson, MI). To classify normality, data from the Spanish population were used, establishing the cut-off point at p10. To assess the level of mobility and the risk of ...

Objective: Cushing’s disease (CD) accounts for approximately 80% of cases of Cushing’s syndrome. Its clinic is nonspecific and its diagnosis difficult. The objective of this study is to review the most frequent clinical signs of this disease in our environment and compare it with that described in the literature.Patients and methods: Retrospective descriptive study of patients with CD. We included all patients diagnosed with CD (2005–2017)...

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...